Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles

Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles

Abstract Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis. We hypothesized that pericytes, a group of pluripotent cells that maintain vascular integrity and tension, are protective against sepsis via regulating vascular reac...

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Bibliographic Details
Main Authors: Zi-Sen Zhang, Yi-Yan Liu, Shuang-Shuang He, Dai-Qin Bao, Hong-Chen Wang, Jie Zhang, Xiao-Yong Peng, Jia-Tao Zang, Yu Zhu, Yue Wu, Qing-Hui Li, Tao Li, Liang-Ming Liu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Military Medical Research
Subjects:
Pericyte
Vascular reactivity
Vascular permeability
Cx43
Microvesicle
Online Access:https://doi.org/10.1186/s40779-023-00442-2

Internet

https://doi.org/10.1186/s40779-023-00442-2

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