Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells

Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells

Abstract Genome editing by homology directed repair (HDR) is leveraged to precisely modify the genome of therapeutically relevant hematopoietic stem and progenitor cells (HSPCs). Here, we present a new approach to increasing the frequency of HDR in human HSPCs by the delivery of an inhibitor of 53BP...

Full description

Bibliographic Details
Main Authors: Ron Baik, M. Kyle Cromer, Steve E. Glenn, Christopher A. Vakulskas, Kay O. Chmielewski, Amanda M. Dudek, William N. Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P. Dever, Matthew H. Porteus
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43413-w

Internet

https://doi.org/10.1038/s41467-023-43413-w

Similar Items