An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors

An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors

Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic regulation in diabetes. In addition to their glucose-lowering effects, SGLT2 inhibitors prevent both renal damage and th...

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Bibliographic Details
Main Authors: Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Luca Rinaldi, Anna Di Martino, Gaetana Albanese, Jessica Di Salvo, Raffaella Epifani, Raffaele Marfella, Giovanni Docimo, Miriam Lettieri, Celestino Sardu, Ferdinando Carlo Sasso
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
type 2 diabetes mellitus
gliflozins
cardiovascular disease
diabetic kidney disease
cardiorenal protection
cardiorenal syndrome
Online Access:https://www.mdpi.com/1422-0067/23/7/3651

Internet

https://www.mdpi.com/1422-0067/23/7/3651

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