miR-6315 Attenuates Methotrexate Treatment-Induced Decreased Osteogenesis and Increased Adipogenesis Potentially through Modulating TGF-β/Smad2 Signalling

miR-6315 Attenuates Methotrexate Treatment-Induced Decreased Osteogenesis and Increased Adipogenesis Potentially through Modulating TGF-β/Smad2 Signalling

Methotrexate (MTX) treatment for childhood malignancies has shown decreased osteogenesis and increased adipogenesis in bone marrow stromal cells (BMSCs), leading to bone loss and bone marrow adiposity, for which the molecular mechanisms are not fully understood. Currently, microRNAs (miRNAs) are eme...

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Bibliographic Details
Main Authors: Ya-Li Zhang, Liang Liu, Yu-Wen Su, Cory J. Xian
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
methotrexate
miR-6315
bone formation
marrow adiposity
TGF-β
Smad2
Online Access:https://www.mdpi.com/2227-9059/9/12/1926

Internet

https://www.mdpi.com/2227-9059/9/12/1926

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