Investigating inhibitors of 1-deoxy-d-xylulose 5-phosphate synthase in a mouse model of UTI

Investigating inhibitors of 1-deoxy-d-xylulose 5-phosphate synthase in a mouse model of UTI

ABSTRACTThe rising rate of antimicrobial resistance continues to threaten global public health. Further hastening antimicrobial resistance is the lack of new antibiotics against new targets. The bacterial enzyme, 1-deoxy-d-xylulose 5-phosphate synthase (DXPS), is thought to play important roles in c...

Full description

Bibliographic Details
Main Authors: Eric C. Chen, Rachel L. Shapiro, Arindom Pal, David Bartee, Kevin DeLong, Davell M. Carter, Erika Serrano-Diaz, Rana Rais, Laura M. Ensign, Caren L. Freel Meyers
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
1-deoxy-d-xylulose 5-phosphate synthase
DXPS
antibiotic
central metabolism
MEP
acetylphosphonate
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03896-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03896-23

Similar Items