Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours

Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours

Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behavior, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a large multi-centre dataset, incorporating volume of activated...

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Bibliographic Details
Main Authors: Flavia Venetucci Gouveia, Jurgen Germann, Gavin JB Elias, Alexandre Boutet, Aaron Loh, Adriana Lucia Lopez Rios, Cristina Torres Diaz, William Omar Contreras Lopez, Raquel Chacon Ruiz Martinez, Erich Talamoni Fonoff, Juan Carlos Benedetti-Isaac, Peter Giacobbe, Pablo M Arango Pava, Han Yan, George M Ibrahim, Nir Lipsman, Andres Lozano, Clement Hamani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
deep brain stimulation
hypothalamus
aggressive behaviour
imaging connectomics
imaging transcriptomics
magnetic resonance imaging
Online Access:https://elifesciences.org/articles/84566

Internet

https://elifesciences.org/articles/84566

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