Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling

Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling

Background Left ventricular (LV) diastolic dysfunction often precedes heart failure with preserved ejection fraction, the dominant form of heart failure in postmenopausal women. The objective of this study was to determine the effect of oral estradiol treatment initiated early after ovariectomy on L...

Full description

Bibliographic Details
Main Authors: Kristofer T. Michalson, Leanne Groban, Timothy D. Howard, Carol A. Shively, Areepan Sophonsritsuk, Susan E. Appt, J. Mark Cline, Thomas B. Clarkson, J. Jeffrey Carr, Dalane W. Kitzman, Thomas C. Register
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
diastolic dysfunction
estrogen
fibrosis
menopause
transcriptome
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009769

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.009769

Similar Items