Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study

Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study

Abstract Background Congenital hydrocephalus occurs with some inheritable characteristics, but the mechanisms of its development remain poorly understood. Animal models provide the opportunity to identify potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one of...

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Bibliographic Details
Main Authors: Hanbing Xu, Masakazu Miyajima, Madoka Nakajima, Ikuko Ogino, Kaito Kawamura, Chihiro Akiba, Chihiro Kamohara, Koichiro Sakamoto, Kostadin Karagiozov, Eri Nakamura, Nobuhiro Tada, Hajime Arai, Akihide Kondo
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Fluids and Barriers of the CNS
Subjects:
Cerebrospinal fluid
Choroid plexus
H-Tx rats
Hydrocephalus
NKCC1 cotransporter
Ventriculomegaly
Online Access:https://doi.org/10.1186/s12987-022-00341-z

Internet

https://doi.org/10.1186/s12987-022-00341-z

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