Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

The KV7.4 and KV7.5 subtypes of voltage-gated potassium channels play a role in important physiological processes such as sound amplification in the cochlea and adjusting vascular smooth muscle tone. Therefore, the mechanisms that regulate KV7.4 and KV7.5 channel function are of interest. Here, we s...

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Bibliographic Details
Main Authors: Damon JA Frampton, Koushik Choudhury, Johan Nikesjö, Lucie Delemotte, Sara I Liin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
docosahexaenoic acid
electrophysiology
KCNQ
lipid
molecular dynamics simulations
omega 3
Online Access:https://elifesciences.org/articles/77672

Internet

https://elifesciences.org/articles/77672

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