Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate

Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate

Asparagine deamidation is a post-translational modification (PTM) that converts asparagine residues into iso-aspartate and/or aspartate. Non-enzymatic asparagine deamidation is observed frequently during the manufacturing, processing, and/or storage of biotherapeutic proteins. Depending on the site...

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Bibliographic Details
Main Authors: Mingyan Cao, G. Patrick Hussmann, Yeqing Tao, Ellen O’Connor, Conner Parthemore, Diana Zhang-Hulsey, Dengfeng Liu, Yang Jiao, Niluka de Mel, Meagan Prophet, Samuel Korman, Jaytee Sonawane, Christina Grigoriadou, Yue Huang, Scott Umlauf, Xiaoyu Chen
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antibodies
Subjects:
deamidation
post-translational modification (PTM)
antibody drug conjugate (ADC)
critical quality attributes (CQAs)
biological activity
Online Access:https://www.mdpi.com/2073-4468/12/4/68

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https://www.mdpi.com/2073-4468/12/4/68

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