Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary

Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary

Abstract Diethylstilbestrol (DES), a strong estrogenic compound, is well-known to affect the reproductive system. In this study, we investigated the effects of DES administration on gonadotropin levels and ovarian steroidogenesis in prepubertal rats. DES treatment acutely reduced serum LH levels, fo...

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Bibliographic Details
Main Authors: Yoshitaka Imamichi, Toshio Sekiguchi, Takeshi Kitano, Takashi Kajitani, Reiko Okada, Yoshihiko Inaoka, Kaoru Miyamoto, Junsuke Uwada, Satoru Takahashi, Takahiro Nemoto, Asuka Mano, Md Rafiqul Islam Khan, Md Tariqul Islam, Koh-ichi Yuhki, Hitoshi Kashiwagi, Fumitaka Ushikubi, Nobuo Suzuki, Takanobu Taniguchi, Takashi Yazawa
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08780-7

Internet

https://doi.org/10.1038/s41598-017-08780-7

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