Intramyocardial delivery of mesenchymal stem cell-seeded hydrogel preserves cardiac function and attenuates ventricular remodeling after myocardial infarction.

Intramyocardial delivery of mesenchymal stem cell-seeded hydrogel preserves cardiac function and attenuates ventricular remodeling after myocardial infarction.

BACKGROUND: To improve the efficacy of bone marrow-derived mesenchymal stem cell (MSC) therapy targeted to infarcted myocardium, we investigated whether a self-setting silanized hydroxypropyl methylcellulose (Si-HPMC) hydrogel seeded with MSC (MSC+hydrogel) could preserve cardiac function and attenu...

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Bibliographic Details
Main Authors: Eva Mathieu, Guillaume Lamirault, Claire Toquet, Pierre Lhommet, Emilie Rederstorff, Sophie Sourice, Kevin Biteau, Philippe Hulin, Virginie Forest, Pierre Weiss, Jérôme Guicheux, Patricia Lemarchand
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527411?pdf=render

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http://europepmc.org/articles/PMC3527411?pdf=render

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