Ball-Milling Preparation of the Drug–Drug Solid Form of Pioglitazone-Rosuvastatin at Different Molar Ratios: Characterization and Intrinsic Dissolution Rates Evaluation

Ball-Milling Preparation of the Drug–Drug Solid Form of Pioglitazone-Rosuvastatin at Different Molar Ratios: Characterization and Intrinsic Dissolution Rates Evaluation

Ball-milling using neat grinding (NG) or liquid-assisted grinding (LAG) by varying the polarity of the solvents allowed access to various drug–drug solid forms of pioglitazone hydrochloride (PGZ·HCl) and rosuvastatin calcium (RSV). Using NG, the coamorphous form was formed from the reaction of piogl...

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Bibliographic Details
Main Authors: M. Fernanda Muñoz Tecocoatzi, José C. Páez-Franco, Kenneth Rubio-Carrasco, Alejandra Núñez-Pineda, Alejandro Dorazco-González, Inés Fuentes-Noriega, Alfredo R. Vilchis-Néstor, Lilian I. Olvera, David Morales-Morales, Juan Manuel Germán-Acacio
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
drug–drug coamorphous
mechanochemical reactions
intrinsic dissolution experiments
rosuvastatin
pioglitazone hydrochloride
Online Access:https://www.mdpi.com/1999-4923/15/2/630

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https://www.mdpi.com/1999-4923/15/2/630

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