Exosomes from cisplatin-induced dormant cancer cells facilitate the formation of premetastatic niche in bone marrow through activating glycolysis of BMSCs

Exosomes from cisplatin-induced dormant cancer cells facilitate the formation of premetastatic niche in bone marrow through activating glycolysis of BMSCs

IntroductionLung cancer is the leading cause of cancer-related deaths worldwide. Chemotherapy kills most cancer cells; however, residual cells enter a dormant state. The dormant cancer cells can be reactivated under specific circumstances. The “premetastatic niche” that is suitable for colonization...

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Bibliographic Details
Main Authors: Jiaqi Xu, Xiang Feng, Na Yin, Lujuan Wang, Yaohuan Xie, Yawen Gao, Juanjuan Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
BMSCs
exosomes
premetastatic niche
IGF-1R
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.922465/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.922465/full

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