Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful using mild conditions (20% Et3N in pyridine, the...

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Bibliographic Details
Main Authors: William Fraser, Michael L. Davis, Andrew J. Walsh
Format: Article
Language:English
Published: MDPI AG 2006-06-01
Series:Molecules
Subjects:
CPG
conjugate
metronidazole
oligonucleotide
phosphoramidite
solid phase.
Online Access:http://www.mdpi.com/1420-3049/11/6/486/

Internet

http://www.mdpi.com/1420-3049/11/6/486/

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