A concise enzyme cascade enables the manufacture of natural and halogenated protoberberine alkaloids
Abstract The application and drug development of plant-derived natural products are often limited by their low abundance in medicinal plants and the lack of structural complexity and diversity. Herein, we design a concise enzyme cascade to efficiently produce natural and unnatural protoberberine alk...
| Auteurs principaux: | , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Nature Portfolio
2025-02-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-025-57280-0 |