RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

Abstract Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing protein 3 (RUFY3) exists as two alternative isoforms distinguishable by the pres...

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Bibliographic Details
Main Authors: Rémy Char, Zhuangzhuang Liu, Cédric Jacqueline, Marion Davieau, Maria-Graciela Delgado, Clara Soufflet, Mathieu Fallet, Lionel Chasson, Raphael Chapuy, Voahirana Camosseto, Eva Strock, Rejane Rua, Catarina R. Almeida, Bing Su, Ana-Maria Lennon-Duménil, Beatrice Nal, Antoine Roquilly, Yinming Liang, Stéphane Méresse, Evelina Gatti, Philippe Pierre
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40062-x

Internet

https://doi.org/10.1038/s41467-023-40062-x

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