Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.

The hedgehog (Hh) pathway has been implicated in the pathogenesis of cancer including pancreatic ductal adenocarcinoma (PDAC). Recent studies have suggested that the oncogenic function of Hh in PDAC involves signaling in the stromal cells rather than cell autonomous effects on the tumor cells. Howev...

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Bibliographic Details
Main Authors: Kazumasa Nakamura, Junpei Sasajima, Yusuke Mizukami, Yoshiaki Sugiyama, Madoka Yamazaki, Rie Fujii, Toru Kawamoto, Kazuya Koizumi, Kazuya Sato, Mikihiro Fujiya, Katsunori Sasaki, Satoshi Tanno, Toshikatsu Okumura, Norihiko Shimizu, Jun-ichi Kawabe, Hidenori Karasaki, Toru Kono, Masaaki Ii, Nabeel Bardeesy, Daniel C Chung, Yutaka Kohgo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2809097?pdf=render

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http://europepmc.org/articles/PMC2809097?pdf=render

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