Nanoparticles of <i>N</i>-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide <i>a</i> as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

Nanoparticles of <i>N</i>-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide <i>a</i> as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

A series of nanoparticles (NPs) with a hydrodynamic radius from 20 to 100 nm in PBS was developed over the solubilization of hydrophobic dye methyl pheophorbide <i>a</i> (chlorin e<sub>6</sub> derivative) by amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates....

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Bibliographic Details
Main Authors: Alexander Yu. Rybkin, Svetlana V. Kurmaz, Elizaveta A. Urakova, Natalia V. Filatova, Lev R. Sizov, Alexey V. Kozlov, Mikhail O. Koifman, Nikolai S. Goryachev
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
nanoparticles
<i>N</i>-vinylpyrrolidone
(di)methacrylates
amphiphilic copolymers
pheophorbide
chlorin e<sub>6</sub>
Online Access:https://www.mdpi.com/1999-4923/15/1/273

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https://www.mdpi.com/1999-4923/15/1/273

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