NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration

NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration

Filamin A, the first discovered non-muscle actin filament cross-linking protein, plays a crucial role in regulating cell migration that participates in diverse cellular and developmental processes. However, the regulatory mechanism of filamin A stability remains unclear. Here, we find that nuclear d...

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Bibliographic Details
Main Authors: Min Liu, Zhangqi Xu, Cheng Zhang, Chunxia Yang, Jiaxing Feng, Yiqing Lu, Wen Zhang, Wenwen Chen, Xiaoyang Xu, Xiaoxia Sun, Mingyang Yang, Wei Liu, Tianhua Zhou, Yuehong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cell migration
filamin A
Hsp90
NudC-L279P
protein stability
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.671233/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.671233/full

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