High‐content screening of drug combinations of an mPGES‐1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance

High‐content screening of drug combinations of an mPGES‐1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance

High‐throughput drug screening enables the discovery of new anticancer drugs. Although monolayer cell cultures are commonly used for screening, their limited complexity and translational efficiency require alternative models. Three‐dimensional cell cultures, such as multicellular tumor spheroids (MC...

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Bibliographic Details
Main Authors: Ahlem Zaghmi, Erdem Aybay, Long Jiang, Mingmei Shang, Julia Steinmetz‐Späh, Fredrik Wermeling, Per Kogner, Marina Korotkova, Päivi Östling, Per‐Johan Jakobsson, Brinton Seashore‐Ludlow, Karin Larsson
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Molecular Oncology
Subjects:
drug screen
MCTS
mPGES‐1
neuroblastoma
PGE2
spheroids
Online Access:https://doi.org/10.1002/1878-0261.13502

Internet

https://doi.org/10.1002/1878-0261.13502

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