Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in <named-content content-type="genus-species">Enterococcus faecalis</named-content>

Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in <named-content content-type="genus-species">Enterococcus faecalis</named-content>

ABSTRACT Enterococcus faecalis strains resistant to penicillin and ampicillin are rare and have been associated with increases in quantities of low-affinity penicillin-binding protein 4 (PBP4) or with amino acid substitutions in PBP4. We report an E. faecalis strain (LS4828) isolated from a prosthet...

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Bibliographic Details
Main Authors: Louis B. Rice, Charlene Desbonnet, Amelia Tait-Kamradt, Monica Garcia-Solache, John Lonks, Thomas M. Moon, Éverton D. D’Andréa, Rebecca Page, Wolfgang Peti
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
antibiotic resistance
Enterococcus
penicillin-binding proteins
Online Access:https://journals.asm.org/doi/10.1128/mBio.00361-18

Internet

https://journals.asm.org/doi/10.1128/mBio.00361-18

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