Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

Abstract The mammalian target of rapamycin (mTOR) signaling pathway efficiently regulates the energy state of cells and maintains tissue homeostasis. Dysregulation of the mTOR pathway has been implicated in several human diseases. Rapamycin is a specific inhibitor of mTOR and pharmacological inhibit...

Full description

Bibliographic Details
Main Authors: Ji Hye Park, Na Kyoung Lee, Hye Ji Lim, Seung taek Ji, Yeon-Ju Kim, Woong Bi Jang, Da Yeon Kim, Songhwa Kang, Jisoo Yun, Jong seong Ha, Hyungtae Kim, Dongjun Lee, Sang Hong Baek, Sang-Mo Kwon
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-020-0374-4

Internet

https://doi.org/10.1038/s12276-020-0374-4

Similar Items