Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

The integrated stress response (ISR) pathway is essential for adaption of various stresses and is related to mitochondrion-to-nucleus communication. Mitochondrial dysfunction-induced reactive oxygen species (ROS) was demonstrated to activate general control nonderepressible 2 (GCN2)–eukaryotic trans...

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Bibliographic Details
Main Authors: Sheng-Fan Wang, Chih-Hsuan Wung, Meng-Shian Chen, Chian-Feng Chen, Pen-Hui Yin, Tien-Shun Yeh, Yuh-Lih Chang, Yueh-Ching Chou, Hung-Hsu Hung, Hsin-Chen Lee
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
gastric cancer
integrated stress response (ISR)
cisplatin resistance
salubrinal
xCT
Online Access:https://www.mdpi.com/1422-0067/19/11/3389

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https://www.mdpi.com/1422-0067/19/11/3389

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