Animal model considerations for chordoma research: reproducing the tumor microenvironment in vivo with humanized mice

Animal model considerations for chordoma research: reproducing the tumor microenvironment in vivo with humanized mice

Animal models have been commonly used in immunotherapy research to study the cell response to external agents and to assess the effectiveness and safety of new therapies. Over the past few decades, immunocompromised (also called immunodeficient) mice allowed researchers to grow human tumor cells wit...

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Bibliographic Details
Main Authors: Beatrice Campilan, Christian Schroeder, Emilija Sagaityte, Jonathan Arditi, Owen P. Leary, Ziya L. Gokaslan, Patricia L. Zadnik Sullivan, Margot Martinez-Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Oncology
Subjects:
chordoma
humanized mice
immunocompromised mice
immunotherapy
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1330254/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1330254/full

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