Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization

Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization

Abstract Background A previous screen of a human kinase and phosphatase shRNA library to select genes that mediate arsenite induction of spindle abnormalities resulted in the identification of phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (PIP4KIIγ), a phosphatidylinositol 4,5-bisphosphate...

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Bibliographic Details
Main Authors: Tz-Chi Lin, Hsiao-Hui Kuo, Yi-Chen Wu, Tiffany S. Pan, Ling-Huei Yih
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell Division
Subjects:
Mitotic centromere-associated kinesin (MCAK)
Microtubule depolymerization
Phosphatidylinositol 4,5-bisphosphate (PIP2)
Phosphatidylinositol 5-phosphate 4-kinase type II gamma (PIP4KIIγ)
Polo-like kinase (PLK1)
Spindle pole
Online Access:http://link.springer.com/article/10.1186/s13008-019-0053-9

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http://link.springer.com/article/10.1186/s13008-019-0053-9

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