Sodium Thiosulfate Improves Intestinal and Hepatic Microcirculation Without Affecting Mitochondrial Function in Experimental Sepsis

Sodium Thiosulfate Improves Intestinal and Hepatic Microcirculation Without Affecting Mitochondrial Function in Experimental Sepsis

IntroductionIn the immunology of sepsis microcirculatory and mitochondrial dysfunction in the gastrointestinal system are important contributors to mortality. Hydrogen sulfide (H2S) optimizes gastrointestinal oxygen supply and mitochondrial respiration predominantly via K(ATP)-channels. Therefore, w...

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Bibliographic Details
Main Authors: Jan Schulz, Sandra Kramer, Yasin Kanatli, Anne Kuebart, Inge Bauer, Olaf Picker, Christian Vollmer, Richard Truse, Anna Herminghaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
sodium thiosulfate
glibenclamide
microcirculation
mitochondria
gut
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.671935/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.671935/full

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