Structural and Functional Characterization of Rv0792c from Mycobacterium tuberculosis: Identifying Small Molecule Inhibitor against HutC Protein

Structural and Functional Characterization of Rv0792c from Mycobacterium tuberculosis: Identifying Small Molecule Inhibitor against HutC Protein

ABSTRACT In order to adapt in host tissues, microbial pathogens regulate their gene expression through a variety of transcription factors. Here, we have functionally characterized Rv0792c, a HutC homolog from Mycobacterium tuberculosis. In comparison to the parental strain, a strain of M. tuberculos...

Full description

Bibliographic Details
Main Authors: Neeraj Kumar Chauhan, Anjali Anand, Arun Sharma, Kanika Dhiman, Tannu Priya Gosain, Prashant Singh, Padam Singh, Eshan Khan, Gopinath Chattopadhyay, Amit Kumar, Deepak Sharma, Ashish, Tarun Kumar Sharma, Ramandeep Singh
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium tuberculosis
GntR transcription factors
HutC subfamily
bacterial pathogenesis
aptamer
SELEX
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01973-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01973-22

Similar Items