Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii

Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii

ABSTRACT Resistance-nodulation-division-type efflux system AdeABC plays an important role in carbapenem resistance among Acinetobacter baumannii. However, a knowledge gap is observed regarding the role of its regulator AdeRS in carbapenem-resistant A. baumannii (CRAB). This study effectively combine...

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Bibliographic Details
Main Authors: Subhasree Roy, Vivek Junghare, Shanta Dutta, Saugata Hazra, Sulagna Basu
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mSystems
Subjects:
Acinetobacter baumannii
AdeABC
AdeRS
PAßN
3D modeling
molecular docking
Online Access:https://journals.asm.org/doi/10.1128/msystems.00217-22

Internet

https://journals.asm.org/doi/10.1128/msystems.00217-22

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