Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading t...

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Bibliographic Details
Main Authors: Ben M. Flude, Giulio Nannetti, Paige Mitchell, Nina Compton, Chloe Richards, Meike Heurich, Andrea Brancale, Salvatore Ferla, Marcella Bassetto
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Viruses
Subjects:
MASP-2
coronaviruses
molecular modelling
drug repurposing
Online Access:https://www.mdpi.com/1999-4915/13/2/312

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https://www.mdpi.com/1999-4915/13/2/312

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