Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells

Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells

Intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary tangles is a hallmark of Alzheimer’s disease (AD). Tau pathology correlates not only with progressive dementia but also with microglia-mediated inflammation in AD. Amyloid-beta (Aβ), another pathogenic peptide i...

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Bibliographic Details
Main Authors: Chinmaya Panda, Clara Voelz, Pardes Habib, Christian Mevissen, Thomas Pufe, Cordian Beyer, Sharad Gupta, Alexander Slowik
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
Alzheimer’s disease
PHF6
tau
microglia
HMC3
autophagy
Online Access:https://www.mdpi.com/2073-4409/10/7/1652

Internet

https://www.mdpi.com/2073-4409/10/7/1652

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