Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology

Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology

Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally-relevant insights. We used cell-type-specific in-vi...

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Bibliographic Details
Main Authors: Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47028-7

Internet

https://doi.org/10.1038/s41467-024-47028-7

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