Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.

Pharmacologic stimulation of innate immune processes represents an attractive strategy to achieve multiple therapeutic outcomes including inhibition of virus replication, boosting antitumor immunity, and enhancing vaccine immunogenicity. In light of this we sought to identify small molecules capable...

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Bibliographic Details
Main Authors: Tina M Sali, Kara M Pryke, Jinu Abraham, Andrew Liu, Iris Archer, Rebecca Broeckel, Julia A Staverosky, Jessica L Smith, Ahmed Al-Shammari, Lisi Amsler, Kayla Sheridan, Aaron Nilsen, Daniel N Streblow, Victor R DeFilippis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005324

Internet

https://doi.org/10.1371/journal.ppat.1005324

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