KHK, PNPLA3 and PPAR as Novel Targets for the Anti-Steatotic Action of Bempedoic Acid

KHK, PNPLA3 and PPAR as Novel Targets for the Anti-Steatotic Action of Bempedoic Acid

Bempedoic acid (BemA) is an ATP-citrate lyase (ACLY) inhibitor used to treat hypercholesterolemia. We studied the anti-steatotic effect of BemA, and the mechanisms involved, in a model of fatty liver in female rats obtained through the administration of a high-fat diet supplemented with liquid fruct...

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Bibliographic Details
Main Authors: Ana Magdalena Velázquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lázaro, Jose Rodríguez-Morató, Rosa María Sánchez, Juan Carlos Laguna, Núria Roglans, Marta Alegret
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
NAFLD
triglycerides
fructose
bempedoic acid
fructokinase
β-oxidation
Online Access:https://www.mdpi.com/2227-9059/10/7/1517

Internet

https://www.mdpi.com/2227-9059/10/7/1517

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