Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model

Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model

Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy. We investigated whether addition of metformin before or during ex vivo i...

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Bibliographic Details
Main Authors: Daan J Touw, Henri G D Leuvenink, Rene A Posma, Leonie H Venema, Tobias M Huijink, Andrie C Westerkamp, A Mireille A Wessels, Nynke J De Vries, Frank Doesburg, J Roggeveld, Petra J Ottens, Maarten W Nijsten
Format: Article
Language:English
Published: BMJ Publishing Group 2020-08-01
Series:BMJ Open Diabetes Research & Care
Online Access:https://drc.bmj.com/content/8/1/e000816.full

Internet

https://drc.bmj.com/content/8/1/e000816.full

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