Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients

Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients

IntroductionADutch-type cerebral amyloid angiopathy (D-CAA) is a hereditary brain disorder caused by a point mutation in the amyloid precursor protein (APP) gene. The mutation is located within the amyloid beta (Aβ) domain of APP and leads to Aβ peptide accumulation in and around the cerebral vascul...

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Main Authors: Elena Daoutsali, Barry A. Pepers, Stavros Stamatakis, Linda M. van der Graaf, Gisela M. Terwindt, David A. Parfitt, Ronald A. M. Buijsen, Willeke M. C. van Roon-Mom
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
in vitro 3D disease modeling
cerebral organoids
Dutch-type cerebral amyloid angiopathy
Aβ accumulations
astrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1048584/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.1048584/full

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