New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity

New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity

Cathepsin V is a human lysosomal cysteine peptidase with specific functions during pathological processes and is as such a promising therapeutic target. Peptidase inhibitors represent powerful pharmacological tools for regulating excessive proteolytic activity in various diseases. Cathepsin V is hig...

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Bibliographic Details
Main Authors: Ana Mitrović, Emanuela Senjor, Marko Jukić, Lara Bolčina, Mateja Prunk, Matic Proj, Milica Perišić Nanut, Stanislav Gobec, Janko Kos
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Cathepsin V
Small-Molecule Inhibitors
Antitumor therapy
Cancer
Cystatin F
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003804

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http://www.sciencedirect.com/science/article/pii/S2001037022003804

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