Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells

Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells

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Isomeric lysosphingolipids, galactosylsphingosine (GalSph) and glucosylsphingosine (GlcSph), are present in only minute levels in healthy cells. Due to defects in their lysosomal hydrolysis, they accumulate at high levels and cause cytotoxicity in patients with Krabbe and Gaucher diseases, respectiv...

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Bibliographic Details
Main Authors: Kamilla Stahl-Meyer, Mesut Bilgin, Lya K. K. Holland, Jonathan Stahl-Meyer, Thomas Kirkegaard, Nikolaj Havnsøe Torp Petersen, Kenji Maeda, Marja Jäättelä
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678304/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678304/?tool=EBI

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