CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart.

CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart.

Natriuretic peptides (NPs) are cardioprotective through the activation of guanylyl cyclase (GC) receptors A and B. CD-NP, also known as cenderitide, is a novel engineered NP that was designed to uniquely serve as a first-in-class dual GC receptor agonist. Recognizing the aldosterone suppressing acti...

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Bibliographic Details
Main Authors: Fernando L Martin, S Jeson Sangaralingham, Brenda K Huntley, Paul M McKie, Tomoko Ichiki, Horng H Chen, Josef Korinek, Gerald E Harders, John C Burnett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3525541?pdf=render

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http://europepmc.org/articles/PMC3525541?pdf=render

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