Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers.
Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rh...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3376118?pdf=render |
| _version_ | 1811266213161992192 |
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| author | Marta Owczarek-Lipska Béatrice Lauber Vivianne Molitor Sabrina Meury Marcin Kierczak Katarina Tengvall Matthew T Webster Vidhya Jagannathan Yvette Schlotter Ton Willemse Anke Hendricks Kerstin Bergvall Ake Hedhammar Göran Andersson Kerstin Lindblad-Toh Claude Favrot Petra Roosje Eliane Marti Tosso Leeb |
| author_facet | Marta Owczarek-Lipska Béatrice Lauber Vivianne Molitor Sabrina Meury Marcin Kierczak Katarina Tengvall Matthew T Webster Vidhya Jagannathan Yvette Schlotter Ton Willemse Anke Hendricks Kerstin Bergvall Ake Hedhammar Göran Andersson Kerstin Lindblad-Toh Claude Favrot Petra Roosje Eliane Marti Tosso Leeb |
| author_sort | Marta Owczarek-Lipska |
| collection | DOAJ |
| description | Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (AD). We performed genome-wide association studies in 161 Labrador Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) levels. We identified a genome-wide significant association on CFA 5 with the antigen-specific IgE responsiveness to Acarus siro. We detected a second genome-wide significant association with respect to the antigen-specific IgE responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. A. siro and T. putrescentiae both belong to the family Acaridae and represent so-called storage or forage mites. These forage mites are discussed as major allergen sources in canine AD. No obvious candidate gene for the regulation of IgE levels is located under the two association signals. Therefore our studies offer a chance of identifying a novel mechanism controlling the host's IgE response. |
| first_indexed | 2024-04-12T20:38:10Z |
| format | Article |
| id | doaj.art-4a49921be4a14af6b22cb002bb36db17 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T20:38:10Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4a49921be4a14af6b22cb002bb36db172022-12-22T03:17:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0176e3917610.1371/journal.pone.0039176Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers.Marta Owczarek-LipskaBéatrice LauberVivianne MolitorSabrina MeuryMarcin KierczakKatarina TengvallMatthew T WebsterVidhya JagannathanYvette SchlotterTon WillemseAnke HendricksKerstin BergvallAke HedhammarGöran AnderssonKerstin Lindblad-TohClaude FavrotPetra RoosjeEliane MartiTosso LeebCrosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (AD). We performed genome-wide association studies in 161 Labrador Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) levels. We identified a genome-wide significant association on CFA 5 with the antigen-specific IgE responsiveness to Acarus siro. We detected a second genome-wide significant association with respect to the antigen-specific IgE responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. A. siro and T. putrescentiae both belong to the family Acaridae and represent so-called storage or forage mites. These forage mites are discussed as major allergen sources in canine AD. No obvious candidate gene for the regulation of IgE levels is located under the two association signals. Therefore our studies offer a chance of identifying a novel mechanism controlling the host's IgE response.http://europepmc.org/articles/PMC3376118?pdf=render |
| spellingShingle | Marta Owczarek-Lipska Béatrice Lauber Vivianne Molitor Sabrina Meury Marcin Kierczak Katarina Tengvall Matthew T Webster Vidhya Jagannathan Yvette Schlotter Ton Willemse Anke Hendricks Kerstin Bergvall Ake Hedhammar Göran Andersson Kerstin Lindblad-Toh Claude Favrot Petra Roosje Eliane Marti Tosso Leeb Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers. PLoS ONE |
| title | Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers. |
| title_full | Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers. |
| title_fullStr | Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers. |
| title_full_unstemmed | Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers. |
| title_short | Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers. |
| title_sort | two loci on chromosome 5 are associated with serum ige levels in labrador retrievers |
| url | http://europepmc.org/articles/PMC3376118?pdf=render |
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