Vhl deletion in Dmp1-expressing cells alters MEP metabolism and promotes stress erythropoiesis

Vhl deletion in Dmp1-expressing cells alters MEP metabolism and promotes stress erythropoiesis

IntroductionErythropoiesis occurs in a specialized niche in the bone marrow and is regulated in part by oxygen-sensing signaling pathways. VHL is an E3 ubiquitin ligase that regulates the degradation of hypoxia-inducible factor (HIF) proteins under normoxic conditions. In hypoxia, VHL is inactivated...

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Bibliographic Details
Main Authors: Janna M. Emery, Betsabel Chicana, Hanna Taglinao, Citlaly Ponce, Cristine Donham, Hawa Padmore, Aimy Sebastian, Scott L. Trasti, Jennifer O. Manilay
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Hematology
Subjects:
bone homeostasis
extramedullary hematopoiesis
HIF signaling
myelopoiesis
polycythemia
red blood cells
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2023.1276426/full

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https://www.frontiersin.org/articles/10.3389/frhem.2023.1276426/full

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