Unleashing the power of complement activation: unraveling renal damage in human anti-glomerular basement membrane disease

Unleashing the power of complement activation: unraveling renal damage in human anti-glomerular basement membrane disease

Anti-glomerular basement membrane (GBM) disease is a rare but life-threatening autoimmune disorder characterized by rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Renal biopsies of anti-GBM patients predominantly show linear deposition of IgG and complement component 3...

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Bibliographic Details
Main Authors: Anqi Tang, Xin Zhao, Tian Tao, Dengpiao Xie, Bojun Xu, Youqun Huang, Mingquan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
anti-glomerular basement membrane disease
complement
autoimmune nephropathy
complement activation
complement therapeutics
emerging therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229806/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229806/full

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