Endothelial Cells Promote Docetaxel Resistance of Prostate Cancer Cells by Inducing ERG Expression and Activating Akt/mTOR Signaling Pathway

Endothelial Cells Promote Docetaxel Resistance of Prostate Cancer Cells by Inducing ERG Expression and Activating Akt/mTOR Signaling Pathway

Docetaxel is a first-line chemotherapy for the treatment of patients with castration-resistant prostate cancer (CRPC). Despite the good initial response of docetaxel, drug resistance will inevitably occur. Mechanisms underlying docetaxel resistance are not well elaborated. Endothelial cells (ECs) ha...

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Bibliographic Details
Main Authors: Wenhao Zhou, Yiming Su, Yu Zhang, Bangmin Han, Haitao Liu, Xiaohai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
endothelial cells
docetaxel
chemoresistance
prostate cancer
FGF2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.584505/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.584505/full

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