Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cells. Overexpression and mislocalization of CENP-A ha...

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Bibliographic Details
Main Authors: Wei-Chun Au, Tianyi Zhang, Prashant K Mishra, Jessica R Eisenstatt, Robert L Walker, Josefina Ocampo, Anthony Dawson, Jack Warren, Michael Costanzo, Anastasia Baryshnikova, Karin Flick, David J Clark, Paul S Meltzer, Richard E Baker, Chad Myers, Charles Boone, Peter Kaiser, Munira A Basrai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008597

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https://doi.org/10.1371/journal.pgen.1008597

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