SOX2 as a novel contributor of oxidative metabolism in melanoma cells

SOX2 as a novel contributor of oxidative metabolism in melanoma cells

Abstract Background Deregulated metabolism is a hallmark of cancer and recent evidence underlines that targeting tumor energetics may improve therapy response and patient outcome. Despite the general attitude of cancer cells to exploit the glycolytic pathway even in the presence of oxygen (aerobic g...

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Bibliographic Details
Main Authors: Elena Andreucci, Silvia Pietrobono, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Barbara Stecca, Lido Calorini
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Melanoma
Tumor extracellular acidosis
SOX2
HIF1α
Oxidative metabolism
Online Access:http://link.springer.com/article/10.1186/s12964-018-0297-z

Internet

http://link.springer.com/article/10.1186/s12964-018-0297-z

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