Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE2 and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages

Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE2 and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages

This article describes the design, synthesis, and in vitro anti-inflammatory screening of new triarylpyrazole derivatives. A total of 34 new compounds were synthesized containing a terminal arylsulfonamide moiety and a different linker between the sulfonamide and pyridine ring at position 4 of the p...

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Bibliographic Details
Main Authors: Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, Yunji Choi, Jungseung Choi, Ji-Sun Shin, Shin-Young Kang, Kyung Ho Yoo, Kyung-Tae Lee, Daejin Baek, Chang-Hyun Oh
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
anti-inflammatory
inducible nitric oxide synthase (iNOS)
nitric oxide
prostaglandine E2
triarylpyrazole
Online Access:http://www.mdpi.com/1420-3049/23/10/2556

Internet

http://www.mdpi.com/1420-3049/23/10/2556

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