Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

Introduction: Genetic variation in the thiopurine S-methyltransferase (TPMT) gene by and large predicts variability in 6-mercaptopurine (6-MP) related toxicities. However, some individuals without genetic variants in TPMT still develop toxicity that necessitates 6-MP dose reduction or interruption....

Full description

Bibliographic Details
Main Authors: Awol Mekonnen Ali, Haileyesus Adam, Daniel Hailu, Ephrem Engidawork, Rawleigh Howe, Teferra Abula, Marieke J. H. Coenen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
acute lymphoblastic leukemia
xanthine dehydrogenase
neutropenia
pharmacogenetics
6-mercactopurine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1159307/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1159307/full

Similar Items