DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation

DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation

Amyloidogenesis is one of the key pathophysiological changes in Alzheimer’s disease (AD). Accumulation of the toxic Aβ results from the catalytic processing of β-amyloid precursor protein (APP) associated β-amyloid converting enzyme 1 (BACE1) activity. It is reported that dead-box helicase 17 (DDX17...

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Bibliographic Details
Main Authors: Yue Liu, Guifeng Zhou, Li Song, Qixin Wen, Shiqi Xie, Long Chen, Lu Wang, Xiaoyong Xie, Xue Chen, Yalan Pu, Guojun Chen
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Brain Sciences
Subjects:
DDX17
amyloidogenesis
BACE1
Alzheimer’s disease
RNA helicase
APP
Online Access:https://www.mdpi.com/2076-3425/13/5/745

Internet

https://www.mdpi.com/2076-3425/13/5/745

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