Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells

Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells

Abstract Background Exposure to cyclophosphamide (CTX) induces premature ovarian insufficiency (POI). Quercetin is a natural flavonoid that exhibits anti-inflammatory and antioxidant properties, and its antioxidant activity is correlated with POI. However, the mechanism underlying its protective rol...

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Bibliographic Details
Main Authors: Yun Chen, Ying Zhao, Chenyun Miao, Liuqing Yang, Ruye Wang, Bixia Chen, Qin Zhang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Ovarian Research
Subjects:
Premature ovarian insufficiency
Cyclophosphamide
Quercetin
Mitochondria
Pyroptosis
Online Access:https://doi.org/10.1186/s13048-022-01080-3

Internet

https://doi.org/10.1186/s13048-022-01080-3

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