The Appearance Order of Varying Intervals Introduces Extra Modulation Effects on Neuronal Firing Through Non-linear Dynamics of Sodium Channels During High-Frequency Stimulations

The Appearance Order of Varying Intervals Introduces Extra Modulation Effects on Neuronal Firing Through Non-linear Dynamics of Sodium Channels During High-Frequency Stimulations

Electrical pulse stimulation in the brain has shown success in treating several brain disorders with constant pulse frequency or constant inter-pulse interval (IPI). Varying IPI may offer a variety of novel stimulation paradigms and may extend the clinical applications. However, a lack of understand...

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Bibliographic Details
Main Authors: Lvpiao Zheng, Zhouyan Feng, Hanhan Hu, Zhaoxiang Wang, Yue Yuan, Xuefeng Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
high-frequency stimulation
inter-pulse interval
in vivo experiment
computational modeling
hippocampal pyramidal cell
membrane dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00397/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.00397/full

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